Determination and Validation of Duloxetine Hydrochloride in Capsules by HPLC with Pre-Column Derivatization and Fluorescence Detection

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Determination and validation of duloxetine hydrochloride in capsules by HPLC with pre-column derivatization and fluorescence detection.

A high-performance liquid chromatographic (HPLC) method is described for the determination of duloxetine hydrochloride in capsules. The method was based on pre-column derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole using the fluorimetric detection technique. Duloxetine hydrochloride was analyzed by HPLC using an Inertsil C18 column (5 μm, 150 × 4.6 mm) and mobile phase consisted of ...

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ژورنال

عنوان ژورنال: Journal of Chromatographic Science

سال: 2012

ISSN: 0021-9665,1945-239X

DOI: 10.1093/chromsci/bms034